Black Stars will play their first two matches in Yaoundé before traveling up North to Garoua for the final Group C encounter.
The Black Stars will take on the Atlas Lions of Morocco in the opening match on Monday, January 10 at the Ahmadou Ahijo stadium in Yaoundé.
The last time Ghana faced Morroco was 2 months ago with the Black Stars losing 1-0.
Ghana will then play Gabon on Friday, January 14 before battling Comoros on Tuesday, January 18, 2021.
The four-time winner of the tournament is in search of their first Africa Cup of Nations title since 1982 and Coach Akonnor has been chored to end the forty-two-year trophy in Cameroon.
Four-time African champions Ghana last won the AFCON in 1982, and Black Stars finished runners-up in 1992, 2010, and 2015.
The 2021 Total Energies Africa Cup of Nations is scheduled for Cameroon from Sunday, January 9 to Sunday, February 6, 2021.